Senior Artificial Intelligence Engineer

High Performance Research Computing (HPRC) and the Center for Bioimage Informatics (CBI) at St. Jude Children's Research Hospital are seeking a Senior AI Engineer to lead our efforts in advanced AI models, including large language models (LLMs), agentic AI systems, and multi-modal foundation models, and the secure computational infrastructure that powers them. This is a hands-on, high-ownership software systems role, not a prompt-engineering, API-integration, or purely conceptual research position.

You will evaluate, fine-tune, deploy, and benchmark AI models; design and enforce safety guardrails and sandboxing for agentic systems; safeguard data security and privacy for sensitive research data; and optimize GPU/HPC resource allocation to balance performance, cost, and efficiency as models and tooling rapidly evolve. This person builds the shared AI architecture, secure environments, and best practices upon which CBI's image data scientists and software engineers rely. Deep bioimaging expertise is not required, though experience with biomedical research or imaging is a plus.

This position reports to the Director of HPRC and works closely with CBI as a collaborative team member. This is an onsite role in Memphis, TN. Job

Assists Research Information Services in ( i ) assessing institution’s needs and (ii) implementing AI-enabled services on high-performance AI computing platforms. Works with scientists, business stakeholders, analysts, and IS professionals in